翻訳と辞書 Words near each other ・ Bagalur ・ Bagalur, Bangalore Urban ・ Bagalur, Krishnagiri ・ Bagalwad ・ Bagam script ・ Bag (album) ・ Bag (Bužim) ・ Bag (disambiguation) ・ Bag (fishing & hunting) ・ Bag (puzzle) ・ Bag (unit) ・ Bag Balm ・ Bag boy (disambiguation) ・ Bag Boy Lover Boy ・ Bag charm ・ BAG domain ・ Bag Enderby ・ Bag face ・ Bag It ・ Bag It (film) ・ Bag It Up ・ Bag It! ・ Bag Københavns kulisser ・ Bag Lady ・ Bag lady ・ Bag Limit ・ Bag limits ・ Bag of Bones ・ Bag of Bones (album) ・ Bag of Bones (miniseries) Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク BAG domain ： ウィキペディア英語版 BAG domain In molecular biology, BAG domains are protein domains found in proteins which are modulators of chaperone activity, they bind to HSP70/HSC70 proteins and promote substrate release. The proteins have anti-apoptotic activity and increase the anti-cell death function of BCL-2 induced by various stimuli. BAG-1 binds to the serine/threonine kinase Raf-1 or Hsc70/Hsp70 in a mutually exclusive interaction. BAG-1 promotes cell growth by binding to and stimulating Raf-1 activity. The binding of Hsp70 to BAG-1 diminishes Raf-1 signalling and inhibits subsequent events, such as DNA synthesis, as well as arrests the cell cycle. BAG-1 has been suggested to function as a molecular switch that encourages cells to proliferate in normal conditions but become quiescent under a stressful environment . BAG-family proteins contain a single BAG domain, except for human BAG-5 which has four BAG repeats. The BAG domain is a conserved region located at the C terminus of the BAG-family proteins that binds the ATPase domain of Hsc70/Hsp70. The BAG domain is evolutionarily conserved, and BAG domain containing proteins have been described and/or proven in a variety of organisms including ''Mus musculus'' (Mouse), ''Xenopus'' spp., ''Drosophila'' spp., ''Bombyx mori'' (Silk moth), ''Caenorhabditis elegans'', ''Saccharomyces cerevisiae'' (Baker's yeast), ''Schizosaccharomyces pombe'' (Fission yeast), and ''Arabidopsis thaliana'' (Mouse-ear cress). The BAG domain has 110-124 amino acids and is composed of three anti-parallel alpha-helices, each approximately 30-40 amino acids in length. The first and second helices interact with the serine/threonine kinase Raf-1 and the second and third helices are the sites of the BAG domain interaction with the ATPase domain of Hsc70/Hsp70. Binding of the BAG domain to the ATPase domain is mediated by both electrostatic and hydrophobic interactions in BAG-1 and is energy requiring. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「BAG domain」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.